Infiuence of parameters of artificial pulmonary ventilation and microaspiration of gastric contents on the frequency of development of neonatal pneumonia

Author(s):  E.Y Bryksina, Dr., Rostov State Medical University , Rostov-on-Don, Russia,

V.S. Bryksin, candidate of Sciences, Municipal budgetary institution of health care Central district hospital of Neklinovsky district , Rostov-on-Don, Russia

A.V. Pochivalov, Dr., Prof., Voronezh state medical university of N.N. Burdenko, Voronezh, Russia,

Issue:  Volume 41, №2

Rubric:  Clinical Medicine

Annotation:  One of the most frequent infectious diseases in nosological structure of the neonatal period is pneumonia. The newborns who are on the artificial pulmonary ventilation (APV) get into risk group on development the ventilator-associated pneumonia (VAP) which frequency increases in process of increase in duration of APV. It is established, that newborns, being on APV in most cases have a microaspiration of gastric contents that does relevant the purpose of the real research: studying of influence of APV and a microas-piration of gastric contents on the frequency of development and feature of a course of neonatal pneumo-nia. Materials and methods. The research included 177 newborns receiving respiratory therapy. The ex-pressiveness of a microaspiration was estimated on the basis of definition of Pepsinum in a tracheobron-chial aspirate (TBA). The diagnosis of VAP was established on the basis of reference clinical and radio-logical criteria. Main results of a research. It is established that the newborns who are on the APV with "rigid" parameters had more frequent cases of pneumonia with the expressed microaspiration of gastric contents. Patients with a combination of a microaspiration and pneumonia had the maximal duration the APV and the subsequent kislorodoterapiya. In a genesis of heavy respiratory frustration in the neonatal period with requirement in the APV with "rigid" parameters contamination of respiratory tracts a Gram-negative microflora, presumably intestinal origin had the greatest statistical significance

Keywords:  artificial pulmonary ventilation, parameters of respiratory therapy, microaspiration of gastric contents, extinction, pneumonia

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