Study of the physicochemical properties of polyvinylpyrrolidone derivatives as thickening agents in ophthalmic solutions

Author(s):  E.T. Zhilyakova, Dr., Prof., Belgorod National Research University, Belgorod, Russia

A.V. Agarina, Belgorod National Research University , Belgorod, Russia

M.Yu. Novikova., candidate of Sciences, associate Professor, Belgorod National Research University , Belgorod, Russia

E.Yu. Timoshenko, Belgorod National Research University , Belgorod, Russia

Issue:  Volume 41, №2

Rubric:  Pharmaceutical Sciences

Annotation:  In the article the characteristic of thickeners-prolongators of polyvinylpyrrolidone (kollidon) is presented. It has been found that they are presented by soluble and insoluble grades having a wide range of proper-ties, which causes their wide application in various branches of the pharmaceutical industry (binders, sta-bilizers, solubilizers, film formers, disintegrants, prolongants, complexing agents (detoxicants).With the selection of a thickener for ophthalmic drug forms of interest are soluble grades (Kollidon 17, 25, 30, 90 and VA 64) in order to select the optimal prolongator possible for use in the ophthalmic solutions, these grades were analyzed by the parameters: density, pH, kinematic and dynamic viscosity and transparen-cy.The dependence of these indices on the brand of the prolongator and its concentration was found. So the most promising brand of polyvinylpyrrolidone was Kollidon 90 in 5% concentration, aqueous so-lutions which allows to achieve the necessary thickening and prolongation at the lowest concentrations

Keywords:  ophthalmology, medicinal preparations, eye drops, prolongators, derivatives of polyvinylpyrrolidone

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