Analysis of association study between polymorphic variants of genes encoding matrix metalloproteinases types 1 and 2 and the risk of ischemic stroke: pilot study in the central Russia population

Author(s):  L.V. Rymarova, Kursk State Medical University, Kursk, Russia

E.Yu. Klyosova, Kursk State Medical University, Kursk, Russia

A.V. Volkova, Academy of Biology and Biotechnologies Southern Federal University , Rostov-on-Don, Russia

O.Yu. Bushueva, candidate of Sciences, associate Professor, Kursk State Medical University, Kursk, Russia

I.E. Azarova, candidate of Sciences, associate Professor, Kursk State Medical University, Kursk, Russia

V.B. Laskov, Dr., Prof., Kursk State Medical University, Kursk, Russia

A.V. Polonikov , Dr., Prof., Kursk State Medical University, Kursk, Russia, polonikov@rambler.ru

Issue:  Volume 41, №2

Rubric:  Clinical Medicine

Annotation:  Polymorphic variants of matrix metalloproteinase genes are an attractive object for testing associations with the risk of ischemic stroke. To date, no studies have been done to assess the contribution of poly-morphisms of matrix metalloproteinase genes in the development of ischemic stroke in Russians. The purpose of this study was to analyze the association between polymorphic variants of the genes encoding matrix metalloproteinases type 1 (MMP1 rs1799750) and 2 (MMP2 rs243865) and the risk of ischemic stroke (IS) in Russians from Central Russia. The results of this study, as well as studies performed in oth-er populations clearly demonstrate the crucial role of synergy in the interaction between polymorphic var-iants of matrix metalloproteinase genes in the predisposition to ischemic stroke, thereby dictating the need for further research in this direction

Keywords:  ischemic stroke, genetic predisposition, matrix metalloproteinases, single nucleotide poly-morphism, association analysis

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