CD4+ AND CD8+ T-lymphocytes in endometrium and their role in early stage miscarriages

Author(s):  I.O. Zhukova, Belgorod National Research University, Belgorod, Russia

O.P. Lebedeva, Dr., associate Professor, Belgorod National Research University, Belgorod, Russia

O.N. Ivashova, Belgorod National Research University, Belgorod, Russia

S.P. Pakhomov, Dr., Prof., Belgorod National Research University, Belgorod, Russia

M.I. Churnosov, Dr., Prof., Belgorod National Research University, Belgorod, Russia

Issue:  Volume 41, №2

Rubric:  Clinical Medicine

Annotation:  The article is devoted to expression of clusters differentiation of T-lymphocytes in endometium of pa-tients with spontaneous and missed abortions in 6-10 weeks of gestation. 34 patients with missed abor-tion, 34 – with miscarriages and 57 patients with progressive pregnancy of the same gestational age, ad-mitted for medical abortion (control group) were studied. Endometrium was obtained during uterine abra-sion. Expression of CD4, CD8 and CD25 mRNA was studied by quantitative PCR. Expression was counted as delta-delta cq. Statistical analysis was pefrormed using Mann-Whitney criteria. No significant differences of CD4 and CD8 expression was detected in patients with missed abortion and spontaneous miscarriages compared with control group. CD25 mRNA expression was significantly higher in patients with missed abortions. As CD25 is a marker of activated lymphocytes, it can be suggested, that this in-crease can stimulate reactions of cell cytotoxicity and therefore contribute to demise of embryo.

Keywords:  miscarriages, spontaneous abortion, missed abortion, endometrium, CD4, CD8, CD25, T-lymphocytes

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