A RARE CLINICAL CASE OF LUNG DISEASE IN SYSTEMIC AMYLOIDOSIS

Author(s):  S.G. Philimonova, Belgorod National Research University, Belgorod, Russia

A.Yu. Tret'yakov, Dr., Prof., Belgorod National Research University, Belgorod, Russia

T.Yu. Lebedev, candidate of Sciences, associate Professor, Belgorod National Research University, Belgorod, Russia

K.S. Aleynikova, Belgorod National Research University, Belgorod, Russia

V.S. Dan, Belgorod National Research University, Belgorod, Russia

E.E. Ernst, Belgorod National Research University, Belgorod, Russia

Issue:  Volume 41, №1

Rubric:  Clinical Medicine

Annotation:  A rare clinical case of diffuse alveolar-septal (parenchymal) variant of pulmonary lesions in systemic AL amyloidosis is presented, with the absence of a typical kidney and liver pathology. It is described the complaints, anamnestic data, results of clinical, laboratory and instrumental examination. It is demon-strated the radiological pattern of the disease and the results of the chest computed tomography. It is de-fined the endoscopic picture of the respiratory tract, the respiratory function is evaluated. Information about of ultrasonic examination of abdominal and retroperitoneal space organs is specified. Diagnostic thoracotomy and biopsy of the lung tissue has performed. The lungs morphology according to the data of histological and immunohistochemical examination is characterized. Alveolar-septal (diffuse) nature of the amyloid deposits distribution has identified that is not peculiar local form of the disease. It is given information about the performed medical treatment. It is concluded that the amyloidosis has to be exclud-ed in the case of unusual clinical progress of lung diseases.

Keywords:  AL amyloidosis, diffuse alveolar-septal pulmonary amyloidosis

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