Variability arterial pressure in meteosensitive patients with arterial hypertension and ischemic heart disease

Author(s):  Je Shcherban, Belgorod Regional Clinical Hospital, Belgorod, Russia, scherban@bsu.edu

R.M. Zaslavskaya, Space Research Institute, Moscow, Russia, rinazaslavskaya@mail.ru

S.I. Logvinenko, Belgorod National Research University, Belgorod, Russia, logvinenko_S@bsu.edu.ru

I.A. Morozova , Scientific Clinical Center, Moscow, Russia, irina-maroz67@list.ru

I.N. Sorokina, Belgorod National Research University, Belgorod, Russia

Issue:  Volume 40, №26

Rubric:  Clinical Medicine

Annotation:  We studied 205 patients (mean age 60.1±3.3 years) with arterial hypertension (AH) II-III stage, grade 2-3 and ischemic heart disease (exertional angina FC I-II, postinfarction cardiosclerosis). The control group of patients received conventional therapy (CT): β-blockers, calcium channel blockers, ACE inhibitors, antiplatelet agents, diuretics and nitrates. The dates of 24-hours ABP monitoring (ABPM) before and after treatment were subjected to correlation analysis with meteorological factors, the values of which were obtained from the server "Weather Russia» (meteo.infospace.ru). Similar studies were conducted in patients receiving drugs with adaptogenic effect (melaxen, mebicar, eltatsin) on the background of the TT. We drew attention to the changes of circadian rhythm and blood pressure variability in the studied patients on the background of the effects of weather on the main hemodynamic parameters. At baseline circadian rhythm with low blood pressure reduction at night and increased variability were found in the majority of studied patients. TT insignificantly reduces the amount of correlation between blood pressure and weather factors, reduces the effect of air temperature and dew point in the state of hemodynamics, but does not reduce the magnetosensitivity of the patients. This normalization of the circadian rhythm is not observed, the variability in systolic blood pressure (SBP) was significantly reduced in the daytime. The treatment with the inclusion melaxen reduces the number and degree of correlation between blood pressure and the meteorological factors (eg, atmospheric pressure, cloud cover top), as well as indices of geomagnetic activity. It is accompanied by a normalization of the circadian rhythm and significant decrease in the variability of systolic and diastolic blood pressure (DBP) at night. The treatment with the inclusion mebicar insignificantly reduces the number and degree of some correlations between blood pressure and weather factors, reduces the influence of the average cloudiness and geomagnetic activity on hemodynamics. Circadian rhythm has not changed, DBP variability significantly decreased in the daytime. The treatment with the inclusion eltatsin reduces the amount of correlation between blood pressure and weather factors, reduces the effect of atmospheric pressure and cloudiness on hemodynamics. However, the normalization of the circadian rhythm and blood pressure variability is not revealed. Thus, melaxen has the most pronounced meteoprotective properties, promotes the normalization of the circadian rhythm, variability, recommended for meteosensitive patients with arterial hypertension and ischemic artery disease

Keywords:  arterial pressure, variability, circadian rhythm, meteorological factors, arterial hypertension, ischemic heart disease

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