Development of technology of liposomal forms of corn silk dry extract

Author(s):  L.G. Dvornikova, candidate of Sciences, associate Professor, Altai State Medical University, Barnaul, Russia, lioubov.dv@mail.ru

N.G. Bekisheva, Altai State Medical University, Barnaul, Russia

O.N. Mazko, candidate of Sciences, Altai State Medical University, Barnaul, Russia

Y.V. Korenovsky, candidate of Sciences, associate Professor, Altai State Medical University, Barnaul, Russia

Issue:  Volume 41, № 4

Rubric:  Pharmaceutical Sciences

Annotation:  The authors of the paper selected the optimal technology of liposomes with corn silk dry extract. Alcohol soluble phospholipids of lecithin, cholesterol and α-tocopherol in a ratio of 30:10:1 was used аs components of the liposomal membrane. Liposomes were prepared by injection, dehydration / rehydration and proliposomes methods. The formation of liposomes was monitored by optical microscopy. A comparative evaluation of the methods for obtaining liposomes was carried out according to parameters: mean size of liposomes, efficiency of inclusion of the extract in liposomes and oxidation index of liposomal phospholipids. The quantitative data were processed statistically using a one-way ANOVA. The optimal method for obtaining liposomes with corn silk dry extract is the proliposomal technology. The optimal ratio of "phospholipids: extract" was 2:1. Proliposomal substance is obtained by grinding the corn silk dry extract and lactose, mixing with phospholipid concentrate and drying to obtain a pulverulent mass

Keywords:  dry extract, corn silk, flavonoids, liposomes, proliposomes

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