METHODS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGES INSULATED LEATHER TISSUE BY AGONISTS OF IMIDAZOLINE RECEPTORS

Author(s):  G.A. Lazareva, Dr., Kursk State Medical University, Kursk, Russia

A.P. Dovgan, Belgorod National Research University, Belgorod, Russia, dovgan@bsu.edu.ru

S.B. Nikolaev, Dr., Prof., Belgorod National Research University, Belgorod, Russia

N.I. Zhernokova, Dr., Prof., Belgorod National Research University, Belgorod, Russia

Issue:  Volume 41, №1

Rubric:  Medical-biological Sciences

Annotation:  In this study, the effect of the agonist of peripheral imidazoline receptors (IR2) C7070 on ischemic skin lesions was studied for the first time. Namely: the search for the possibility of pharmacological correction of ischemic circulation disorders in the microvascular bed of the skin by introducing exogenous ligands of peripheral imidazoline receptors (IR2). Namely: the search for the possibility of pharmacological correc-tion of ischemic circulation disorders in the microvascular bed of the skin by introducing exogenous lig-ands of peripheral imidazoline receptors (IR2). Materials and methods. Drug-induced (chloral hydrate 300 mg / kg) in rats divided into 4 subgroups (con-trol (ischemia), ischemia + metformin (50 mg/kg), ischemia+moxonidine (1 mg/kg), ischemia+C7070 (10 mg/kg)) formed an isolated cutaneous incision on the feeding leg according to the method described by E. Kizhaev. On the 3rd, 7th and 10th day planimetric calculation of the area of necrosis of the skin flap was made. On the basis of the data obtained, the corresponding coefficients of dermatoprotective activity for the studied drugs were derived. Results of the study. As a result of the study, the following coefficients of dermatoprotective activity were obtained: C7070 69.49/62.76/81.67, moxonidine 79.35/77.11/91.47; metformin - 82.41/90.61/92.76 for 3/7/10 days, respectively. Conclusions. Thus, the agonist of peripheral imidazoline receptors C7070 significantly and significantly exhibits stronger dermatoprotective properties, in comparison with the central imidazoline receptor ago-nist moxonidine and biguanide metformin.

Keywords:  imidazoline receptors, moxonidine, C7070, metformin, dermatoprotective activity, anti-ischemic activity, diabetes mellitus.

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