METASTASES OF BREAST CARCINOMA SIMULATING THE PRIMARY STOMACH CANCER. A CASE REPORT AND REVIEW OF DIAGNOSTIC PROBLEMS

Author(s):  N.V.Pavlova, Belgorod onkology dispensary, Belgorod, Russia

M.I. Churnosov, Dr., Prof., Belgorod National Research University, Belgorod, Russia

A.A. Dolzhikov, Dr., Prof., Белгородский государственный национальный исследовательский университет, Belgorod, Russia, dolzhikov@bsu.edu.ru

T.S. Mukhina, Belgorod Pathoanatomical Bureau, Belgorod, Russia

Issue:  Volume 41, №1

Rubric:  Medical-biological Sciences

Annotation:  The breast cancer takes the leading place among the malignant women’s tumors. Tumors often forms atypical metastases, including gastro-intestinal tract. The aim of presented work is description of morpho-logical features of gastric metastases of relatively rare signet-ring cell variant of lobular breast carcino-ma.masquerating as primary stomach cancer- linitis plastica. Diagnosis was definitely made on the basis of pathological features of metastatic cells supported by immunohistochemical findings. The former in-clude the tendency of invasive cells to be dispersed or to form infiltrative chains, like primary infiltrative carcinoma of the breast. The intracytoplasmic mucus is usually of monovacuolar type seen as an eosino-philic drop-like inclusion and consisting of acid mucins easily detected with alcian blue stain. Among the immunohistochemical features most informative are expression of cytokeratin 7, steroid receptors and GATA-3. The modern literature data concerning the problem are reviewed.

Keywords:  breast carcinoma, stomach metastases, diagnostics

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