FORMULATION AND TECHNOLOGY INFLUENCE ON RELEASE RATE OF DRUG FROM TABLETS IN CASE OF PARACETAMOL

Author(s):  N.I. Filippova, Saint-Petersburg State Chemical-Pharmaceutical Academy, Saint-Petersburg, Russia, natalia.philippova@pharminnotech.com

V.А. Vainshtein, Dr., Prof., Saint-Petersburg State Chemical-Pharmaceutical Academy, Saint-Petersburg, Russia

P.S. Gretskov, Saint-Petersburg State Chemical-Pharmaceutical Academy, Saint-Petersburg, Russia

Issue:  Volume 41, №1

Rubric:  Pharmaceutical Sciences

Annotation:  The influence of granulation technology and prolongation polуmer content on technological properties of obtained granules and drug release was investigated on paracetamol. The comparison of three introduction types of granulation polymer solution (HPMC) in granules formula-tions was researched. There are: polymer application on granules surface in pelletizer, polymer applica-tion in fluid bed dryer and formulation granulation in high-shear mixer. Properties of obtained granules and tablets from these granules were observed. The addiction of paracetamol release speed and rate from granulation technology and amount of polymer in granules formulation was investigated. It was found, that granulation method in mixer allowed getting granules and tablets with optimal technological proper-ties and better reproducibility of technological process. The HPMC addition of within 15-30% permits to regulation of drug release in 2-4 hours. That is useful factor for non-steroidal anti-inflammatory drugs (NSAIDs) substances having local irritating effect.

Keywords:  granulation, fluid bed dryer, high-shear mixer, HPMC, paracetamol, sustain release

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