TECHNOLOGY DEVELOPMENT AND STANDARDIZATION OF HEATHER SHOOTS TINCTURE

Author(s):  О.А. Veremchuk, Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus, veremchuk.oa@gmail.com

D.V. Moiseev, candidate of Sciences, associate Professor, Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Republic of Belarus, ussr80@ya.ru

Issue:  Volume 41, №1

Rubric:  Pharmaceutical Sciences

Annotation:  The aim of the study was to optimize heather shoots tincture preparation as well as to develop quality pa-rameters for finished product. The effects of extragent concentration, raw material-extragent ratio, num-ber of extractions and extractionmode accompanied by supporting technologies (ultrasound treatment) on the yield of biologically active compounds of heatherwere investigated. Maceration accompanied by ul-trasound treatment was established to be the most acceptable method of heather shoots tincture prepara-tion. Using the above mode of extraction enables to get tinctures with 59.6±2.5% of total flavonoids yield and spending minimum time. Specified quality parameters of finished product, including ethanol (55.0% to 65.0%), specific gravity(0.873 to 0.965 g/cm3), residue on evaporation (not less than1.0%), total flavo-noids taken on isoquercitrin (not less than 0.80 mg/ml or not less than 0.08%), were identified during this study.Finished heather shoots tincture was stable for 24 months under room temperature and 65±5% rela-tive humidity, protected from light.

Keywords:  Calluna vulgaris, tincture, maceration, standardization.

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