хронические формы ишемической болезни сердца, ишемическая кардиомиопатия, перенесенный инфаркт миокарда, сменный график с ночным временем работы, уровень 6-сульфатоксимелатонина, клинические проявления болезни.

Author(s):  E.I. Myasoedova, candidate of Sciences, no, Astrakhan State Medical University, Astrakhan, Russia

P.N. Voronina, Astrakhan State Medical University, Astrakhan, Russia

Issue:  Volume 42, № 3

Rubric:  Cardiology

Annotation:  The purpose of the study is to study the characteristics of the work rhythm and 6-sulfatoxymelatonin level in patients with chronic forms of coronary heart disease (CHD) and to identify their relationship with the clinical manifestations of the disease, as well as to assess the risks and chances of developing ischemic cardiomyopathy in patients after Q-forming myocardial infarction (MI) depending on the characteristics of the labor rhythm in history. Materials and methods. The study included 240 patients with chronic forms of coronary heart disease who had Q-forming myocardial infarction: 110 patients with coronary artery disease: myocardial infarction with preserved left ventricular ejection fraction (PIM-LVEF) and 130 patients with coronary heart disease: ischemic cardiomyopathy (ICMP). The level of 6-sulfatoxymelatonin (6-COMT) in morning urine samples was determined using the Buhlmann 6-Sulfatoxymelatonin ELISA test system (Switzerland). Results. The number of patients with a changeable schedule and night work hours in the group of patients with ICMP was statistically significantly more than in the group of patients with PIM-LVEF (2=4,04; df=1; p=0,044). The level of 6-COMT in both groups was statistically significantly lower than the control values (p <0,001 and p<0,001, respectively), while in the PIM-LVEF group it exceeded the values of patients of the ICMP group (p = 0,002). At the same time, both in the ICMP group and in the PIM-LVEF in the subgroups of patients with a changeable schedule and overnight work time in history, the level of 6-COMT was statistically significantly lower than in the subgroup with the daily work schedule. In both groups, statistically significant interrelationships of the shift schedule with night work time history and 6-COMT level with the stage and functional class of chronic heart failure and angina, systolic blood pressure (in the PIM-LVEF group), as well as the presence of a permanent form of fibrillation auricles The calculations in the study showed that the risk of ICMP in patients with a shift schedule and overnight work history is elevated relative to patients with a daily work schedule.

Keywords:  chronic forms of ischemic heart disease, ischemic cardiomyopathy, myocardial infarction, shift schedule with night work time, 6-sulfatoxymelatonin level, clinical manifestations of the disease.

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