System condition of oxidative stress - antioxidant protection in patients with chronic pyelonephritis

Author(s):  О.А. Efremova, Dr., Prof., Belgorod National Research University, Belgorod, Russia

L.A. Kamyshnikova, Belgorod National Research University, Belgorod, Russia, kamyshnikova@bsu.edu.ru

S.E. Veysalov, Belgorod National Research University, Belgorod , Russia

M.S. Sviridova, candidate of Sciences, Belgorod National Research University, Belgorod , Russia

M.M. Kiselevich, candidate of Sciences, associate Professor, Belgorod National Research University, Belgorod, Russia, marianna1970@live.ru

Issue:  Volume 42, № 2

Rubric:  Internal diseases

Annotation:  In this work, an imbalance in the system of oxidative stress – antioxidant protection in patients with chronic pyelonephritis was evaluated depending on the course of the disease. Markers of oxidative stress (OS) in the serum were determined by the content of secondary products of lipid peroxidation (LPO) – malonic dialdehyde (MDA) and diene conjugate (DC). The activity of the antioxidant system was assessed by the activity of superoxide dismutase (SOD) and catalase (Cat). It was found that patients with recurrent pyelonephritis (CPr) are characterized by an increase in OS activity and an increase in MDA production against the background of reduced antioxidant protection parameters, and the relapsing CP course produced a more significant effect on changes in these indicators: for patients with CPr (with 3 or more relapses after year) were characterized by lower SOD values and Cat compared with the same indicators in the group of patients with chronic pyelonephritis without relapse. For patients with chronic pyelonephritis with comorbid pathology compared with the control group, in general, there was a violation of the oxidative-oxidative balance, which was manifested by an increase in the average indices of the content of MDA and DС in blood serum (by 12,3 and 9,1 %, respectively, p < 0,001) against the background of a decrease in the average content of cat (by 18,2 %, p < 0,001) and a pronounced tendency to decrease SOD. Compared with the relapsing course of pyelonephritis (CPr), oxidative stress was more pronounced in patients with comorbid pathology, which was manifested in a significantly greater increase of LPO and a decrease of antioxidant protection parameters. It is possible that increased free radical activity is one of the factors involved in the pathogenesis of the inflammatory syndrome in patients with chronic pyelonephritis with comorbid pathology.

Keywords:  pyelonephritis, free radical activity, comorbid pathology, oxidative stress, lipid peroxidation, antioxidant system.

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