Author(s):  M.S. Turchina, candidate of Sciences, associate Professor, Orel State University named by I.S. Turgenev, Orel, Russia, turchina-57@mail.ru

T.I. Obolenskaya, candidate of Sciences, associate Professor, Orel State University, Orel, Russia

Yu.M. Morozov, Dr., Prof., Orel State University, Orel, Russia

Zh.E. Annenkova, candidate of Sciences, associate Professor, Orel State University, Orel, Russia

L.G. Polyakov, Orel State University, Orel, Russia

Issue:  Volume 42, № 1

Rubric:  Internal diseases

Annotation:  Currently, the incidence of gallstone disease has increased significantly, and cholecystectomy is one of the most frequently performed surgical interventions. Moreover, after the surgical treatment of cholelithiasis, about half of the patients develop postcholecystectomy syndrome, caused in most cases by the development of functional disorders of the Oddi's sphincter and intestines. As part of this study, the issues of outpatient treatment of patients with burdened allergic anamnesis who underwent cholecystectomy are considered. In comparison with patients who do not have chronic allergic diseases, in this case more frequent development of functional disorders with a more pronounced dyspeptic syndrome is observed. In addition, in the case of the development of postcholecystectomy syndrome in patients with aggravated allergic anamnesis, violations of the qualitative and quantitative composition of the intestinal microbiota with excessive growth of conditionally pathogenic microflora, contributing to the development of diarrhea are more common. In turn, this leads to a deterioration in the quality of life and requires a more prolonged and massive drug therapy, increasing the cost of treatment.

Keywords:  gallstone disease, postcholecystectomy syndrome, allergy, ambulatory intake, quality of life

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