The effect of thiotriazoline on the state of cellular and humoral immunity in patients with community-acquired pneumonia

Author(s):  V.I. Vishnevsky, Dr., Prof., Orel State University named by I.S. Turgenev, Orel, Russia

I.I. Mironenko, candidate of Sciences, associate Professor, Orel State University named after I.S. Turgenev, Orel, Russia, mivan@list.ru

O.V. Demyanenko, candidate of Sciences, associate Professor, Orel State University named after I.S. Turgenev, Orel, Russia

Issue:  Volume 41, № 4

Rubric:  Clinical Medicine

Annotation:  In 149 patients with community-acquired pneumonia, the influence of the antioxidant tiotriazoline on the state of cellular and humoral immunity was studied. Studies have shown that out-of-hospital pneumonia occurs against the background of secondary immunodeficiency, which is manifested by a decrease in the total circulating T-lymphocytes and their subpopulations: NK-cells, T-helper cells, T-suppressors, Ig A and Ig G increase in Ig M decrease. Tiotriazoline in the complex therapy of patients with community-acquired pneumonia is accompanied by a decrease in both total T-lymphocytopenia and their subpopulations against the background of an increase in the content of immunoglobulins of class Ig M reduction in immunoglobulin classes Ig A and Ig G.

Keywords:  community-acquired pneumonia, cellular immunity, humoral immunity, immunoglobulins, tiotriazolin, efficacy of treatment

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