Modern aspects of pathogenesis acute hematogenous osteomyelitis

Author(s):  S.V. Kostin, candidate of Sciences, associate Professor, Kursk State Medical University, Kursk, Russia, drkostin@inbox.ru

V.P. Gavriliuk, Dr., associate Professor, Kursk State Medical University, Kursk, Russia

D.A. Severinov, Kursk State Medical University, Kursk, Russia

M.I. Statina, Kursk State Medical University, Kursk, Russia

Issue:  Volume 41, № 4

Rubric:  Clinical Medicine

Annotation:  Acute hematogenous osteomyelitis is one of the most severe purulent-septic diseases, leading to late diagnosis and inadequate treatment to the development of severe septic complications with the development of multiple organ failure, septic shock before death. The aim of the study was to analyze the localization of lesions and assess the level of cytokines, activity of the complement system and peripheral blood neutrophils in acute hematogenous osteomyelitis. 38 patients with acute hematogenous osteomyelitis of long tubular bones with local and septicopyemical forms were under constant observation. Significant differences in the localization of the pathological focus in children with acute hematogenous osteomyelitis, depending on the form of the disease, have not been established. In patients with a septicpyemical form of acute hematogenous osteomyelitis in the blood plasma at admission to the clinic, more pronounced changes in the concentration of cytokines, activation of the complement system and multidirectional changes in the neutrophils functional metabolic activity were found. The revealed changes in the immune status after the surgical and conservative treatment of patients with acute hematogenous osteomyelitis are not fully corrected, which dictates the need to search for and test effective means and methods of immunorehabilitation

Keywords:  acute hematogenous osteomyelitis, immunity

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