Cytokine levels in postmenopausal women depending on IL-6, TNFSF11 and TNFRSF11B genes polymorphisms

Author(s):  E.A. Maylyan, Dr., associate Professor, Donetsk National Medical University named after M. Gorky, Donetsk, Ukrain, mea095@yandex.ru

Issue:  Volume 41, №2

Rubric:  Clinical Medicine

Annotation:  Concentrations of IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (INF-γ), osteoprotegerin and receptor activator of nuclear factor kappa-B ligand (RANKL) are investigated in blood serum samples of 180 postmenopausal women. Results were analyzed depending on degree of bone tissue osteoporotic changes and genetic polymorphisms of IL-6 (rs1800795), TNFSF11 (rs9594738, rs9594759), TNFRSF11B (rs3134069, rs3102735) genes. It is established that patients with postmenopausal osteoporosis had increased IL-1β, IL-8, IL-17A, TNF-α, RANKL concentrations, but decreased IL-4, IL-10 ones (P <0,05). Similar changes in levels of most of above-stated cytokines are de-tected also at patients with genotypes of IL-6 and TNFSF11 genes polymorphisms, which were also postmenopausal osteoporosis predictors. TNFRSF11B (rs3134069 and rs3102735) gene polymorphic op-tions had no associations with changes of the studied cytokines levels. The obtained data reflect important pathogenetic aspects of postmenopausal osteoporosis, including depending on genetic factors, and can be used for development of the individualized schemes of treatment-and-prophylactic actions

Keywords:  genes, IL-6, TNFSF11, TNFRSF11B, polymorphisms, cytokines, women, postmenopause, osteoporosis

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