Adenosintrifosphoric acid in the blood as a marker of the state of the energy exchange of the myocardium at the evaluation of the energy-saving effects of metabolic correctors

Author(s):  V.G. Kukes , First Moscow State Medical University. named by I.M. Sechenov, Moscow, Russia

T.V. Gorbach, Kharkov National Medical University, Kharkov, Ukraine

O.V. Romaschenko, Belgorod National Research University, Belgorod, Russia, Romashenko@bsu.edu.ru

V.V. Rumbesht, Belgorod National Research University, Belgorod, Russia, rumbesht@bsu.edu.ru,

L.R. Zakirova, Belgorod National Research University, Belgorod, Russia

P.K. Alferov, Belgorod Regional Clinical Hospital of St. Joasaph, Belgorod, Russia

V.S. Gritsenko, Krasnodar state institute of culture, Krasnodar, Russia, postmodernist@mail.ru

L.B. Statsenko, Belgorod Regional Clinical Hospital of St. Joasaph, Belgorod, Russia

N.S. Gorbunova, Belgorod Regional Clinical Hospital of St. Joasaph, Belgorod, Russia

Issue:  Volume 40, №26

Rubric:  Medical-biological Sciences

Annotation:  In order to determine an adequate marker of the state of myocardial energy metabolism when assessing the energy-saving effects of metabolic correctors, an experimental study was performed on 60 male Wistar rats with modeling of myocardial ischemia.Energy-saving effects of trimetazidine, meldonium, cytoflavin, and phosphocreatine were found in rats with myocardial ischemia, which were achieved in different ways and in varying degrees.The concentration of adenosine triphosphate (ATP) in blood serum and / or erythrocytes closely correlated with the level of ATP in myocardial homogenate and with the activity of mitochondrial enzymes of the heart - succinatedehydrogenase (SDG), citratesynthase (CA), pyruvatedehydrogenase (PDH), and therefore this indicator can be recommended to the study to assess the effectiveness of cardiac cytoprotectors as the most appropriate marker for their energy-saving effect

Keywords:  cardiocytoprotection, energy-saving effect, metabolic correctors, trimetazidine, meldonium, cytoflavin, phosphocreatine, ATP, myocardial metabolism

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