A study of the potential use of sodium alginate in microencapsulation of vinpocetine

Author(s):  Yu.A. Polkovnikova, Voronezh State University, Voronezh, Russia, juli-polk@mail.ru

A.A. Glushko, Pyatigorsky Medical and Pharmaceutical Institute – branch of FGBOU in VolgGMU Ministry of Health of Russia, Pyatigorsk, Russia

Issue:  Volume 40, №26

Rubric:  Pharmaceutical Sciences

Annotation:  Microencapsulation is a method of producing traditional materials in a unique shape that is able to protect substances fr om the action of environmental factors that cause their decomposition. This technique finds application in medicine and pharmacy, wh ere medicines and enzymes are enclosed in biodegradable microcapsules. In the article using the methods of quantum chemistry the possibility of the use of sodium alginate as the film former in the microencapsulation of the drug substance Vinpocetine. The molecular simulation of the process of release of Vinpocetine from the microcapsules in different environments: water with pH=2 and 7, 95% ethyl alcohol. The method of molecular dynamics in the program of Bioeurica used to simulate "polymer-Vinpocetine" systems in water and ethanol environments. Calculated values of enthalpy, entropy and Gibbs energy of Vinpocetine release from the polymer. The studies of the molecular dynamics modelling of the release of Vinpocetine showed that the release of Vinpocetine from sodium alginate in water with pH=2 is energetically more favorable process than release in water with pH=7 and ethanol. The affinity of Vinpocetine to sodium alginate in the environment of ethanol is higher compared to the aqueous medium. The obtained results allow to conclude about the prospects of the use of sodium of sodium alginate and conduct pharmaceutical research in the environment of hydrochloric acid.

Keywords:  microcapsules, vinpocetine, sodium alginate, molecular dynamics, release rate, quantum chemistry

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